Is SPRAVATO® Effective for Treatment-Resistant Depression?

In short…

• SPRAVATO® offers rapid relief for treatment-resistant depression (TRD).
• This treatment is specifically for adults diagnosed with TRD.
• Discuss SPRAVATO® with your provider to see if it’s right for you.

SPRAVATO® has gained a reputation for being a highly effective treatment-resistant depression treatment. According to a study published by the National Institutes of Health, two separate trials demonstrated that those with major depressive disorder who were administered SPRAVATO® experienced significant improvement within 24 hours of their first dose.

This article will explore what SPRAVATO® really is, how it works, and how it benefits patients who are looking for relief.

What is Treatment-Resistant Depression?

Treatment-resistant depression (TRD) is depression that hasn’t improved after trying at least two different antidepressant medications at adequate doses and durations.

TRD significantly impacts daily functioning and, according to the National Institutes of Health, it impacts at least 30 percent of individuals diagnosed with major depressive disorder.

What are the Symptoms of Treatment-Resistant Depression?

Individuals with TRD often experience life-altering symptoms, including:

• Persistent feelings of sadness, hopelessness, and worthlessness.
• Fatigue and sleep disturbances.
• Changes in appetite.
• Difficulty concentrating.

TRD can also increase the risk of suicidal thoughts and behaviors, highlighting the need for effective interventions.

What Causes Treatment-Resistant Depression?

The exact causes of TRD are not fully understood, but research suggests a complex interplay of biological, psychological, and environmental factors.

Biological Factors

It is widely thought that genetic predisposition may play a role in the development of TRD. Other contributing factors include neurotransmitter imbalances, such as:

• Serotonin
• Norepinephrine
• Dopamine

Psychological and Environmental Factors

Life experiences, living environments, and other social and psychological factors can be risk factors. These include:

• Chronic stress
• Trauma
• Adverse childhood experiences
• Co-occurring mental health conditions, such as anxiety disorders or substance use disorders
• Lack of social support
• Consistent isolation

Medical Conditions and Medications

It’s important to note that some medications and medical conditions may include side effects or mimic symptoms of depression.

Healthcare professionals typically look out for:

• Certain medical conditions, such as hypothyroidism and chronic pain, which can mimic or exacerbate depression symptoms.
• Specific medications, such as corticosteroids and beta-blockers, can induce depressive symptoms.

SPRAVATO®: A Novel Treatment for Treatment-Resistant Depression

SPRAVATO® (esketamine) represents a significant advancement in the treatment of treatment-resistant depression (TRD). Unlike traditional antidepressants, SPRAVATO® works through a different mechanism of action, offering hope for individuals who haven’t found relief with conventional treatments.

What is SPRAVATO®?

SPRAVATO® (esketamine) is a nasal spray medication approved by the FDA for the treatment of treatment-resistant depression in adults.

It works differently from traditional antidepressants by targeting the NMDA receptor in the brain. Because of its innovative mechanics, SPRAVATO® must be administered under the supervision of a healthcare provider in a certified treatment center.

How Does SPRAVATO® Work?

SPRAVATO® is believed to increase levels of glutamate, a neurotransmitter that plays a role in mood regulation. By modulating glutamate activity, it can help restore connections between brain cells and improve mood.

It is important to note that SPRAVATO® is typically used in conjunction with an oral antidepressant.

SPRAVATO® vs. Traditional Antidepressants

SPRAVATO® differs significantly from traditional antidepressants in its mechanism, administration, and speed of action. While both aim to alleviate symptoms of treatment-resistant depression, SPRAVATO® offers a unique approach for individuals who may not respond well to standard antidepressant treatments.

• Mechanism of Action: Traditional antidepressants typically work by affecting serotonin, dopamine, or norepinephrine levels over time. SPRAVATO®, however, targets the NMDA receptor, leading to quicker changes in brain function.
• Administration: Unlike traditional antidepressants taken orally, SPRAVATO® is administered as a nasal spray under medical supervision in a clinical setting.
• Onset of Effects: Traditional antidepressants often take weeks to show results, whereas SPRAVATO® has been reported to provide relief within hours for some patients.

What Can I Expect During SPRAVATO® Treatment?

Embarking on SPRAVATO® treatment involves an initial assessment, administration, and ongoing monitoring. Open communication with your healthcare provider is essential throughout the process.

1.      Initial Assessment and Evaluation

A thorough psychiatric evaluation is necessary to determine if SPRAVATO® is appropriate for you. This evaluation may include a review of:

• Your medical history.
• Current medications.
• Previous treatment experiences.

Your provider will discuss the potential benefits and risks of SPRAVATO® with you.

2.      The SPRAVATO® Administration Process

SPRAVATO® is administered as a nasal spray in a certified treatment center. During treatment, you will self-administer the nasal spray under the supervision of your healthcare professional.

After each dose, you will be monitored for at least two hours for potential side effects.

3.      Potential Side Effects and Monitoring

Common side effects of SPRAVATO® include:

• Dissociation
• Increased blood pressure
• Nausea
• Sedation

Your blood pressure may also be monitored before and after each dose.

You will be advised not to drive or operate heavy machinery until the day after each treatment session, so it is important to arrange for someone to drive you home from your appointment.

How Do I Maximize the Benefits of My Treatment-Resistant Depression Treatment?

To maximize the benefits of treatment-resistant depression treatment, including SPRAVATO®, it’s essential to adopt a holistic approach that combines medication with other therapies and lifestyle modifications.

Combine SPRAVATO® with Other Therapies

Combining SPRAVATO® with other treatments can help enhance its efficacy. Consider:

• Psychotherapy (talk therapy) sessions that incorporate cognitive behavioral therapy.
• Lifestyle changes to help manage stress and support a balanced mindset.
• Joining a support group to connect with others who also experience TRD.

Make Lifestyle Adjustments to Support Mental Health

Making simple lifestyle adjustments can support your mental health journey. It is often recommended that patients with TRD try to:

• Prioritize sleep hygiene by establishing a regular sleep schedule and creating a relaxing bedtime routine.
• Engage in regular physical activity, such as walking, jogging, or swimming.
• Practice mindfulness and relaxation techniques, such as meditation or deep breathing exercises.

Employ Key Strategies for Managing Treatment-Resistant Depression

There are many ways in which patients can manage their treatment-resistant depression. Key strategies to implement include:

• Maintain open communication with your provider about your symptoms and any concerns you may have.
• Adhere to your treatment plan, including taking your medications as prescribed and attending therapy sessions.
• Be patient and persistent, as it may take time to find the most effective treatment approach.

When Should I Seek Professional Treatment-Resistant Depression Treatment?

Recognizing when to seek professional help for TRD is crucial. If you are in immediate danger or experiencing active suicidal thoughts, call or text 988 (Suicide & Crisis Lifeline) or go to the nearest emergency room immediately.

At My Buoyant Health in Phoenix, Arizona, we offer comprehensive TRD treatment, including SPRAVATO®.

Recognize Warning Signs

Watch out for warning signs of TRD, including:

• Worsening of depressive symptoms despite ongoing treatment.
• Increased suicidal thoughts or behaviors.
• Significant changes in appetite, sleep, or energy levels.
• Feelings of being overwhelmed or unable to cope.
• Thoughts of death or dying.

Find a Qualified Provider

Seek out a psychiatrist or other mental health professional who specializes in the treatment of TRD.

If you are interested in SPRAVATO® for treatment-resistant depression treatment, ensure that your preferred provider is experienced in administering SPRAVATO® and managing potential side effects.

Experience Effective Treatment-Resistant Depression Treatment in Phoenix, AZ

At My Buoyant Health, we specialize in offering effective treatment for treatment-resistant depression through SPRAVATO® (esketamine). Our skilled providers are extensively trained to administer this innovative therapy in a safe, comfortable, and supportive environment. We are dedicated to creating a welcoming space where patients can find relief, regain hope, and take meaningful steps toward reclaiming their well-being.

To learn more about SPRAVATO® or to get started on your journey to a more balanced life, call My Buoyant Health today at (602) 510-6582 or use our online appointment request form.